Detecting Inequity in Dendritic Cells Through Bio-Inspired Synthetic T Cells

Multivalent Presentation of TCRs on DNA Nanostructures as a Sensitive Probe for pMHC Detection

K Paloja, HJ Rodríguez-Franco, R Jungmann, IA Parish, MMC Bastings

2025-06-20

Dendritic cells (DCs) are key regulators of immune responses, presenting antigen-derived peptides on major histocompatibility comp..

Balancing the Nanoscale Organization in Multivalent Materials for Functional Inhibition of the Programmed Death-1 Immune Checkpoint

Kaltrina Paloja, Jorieke Weiden, Joschka Hellmeier, Alexandra S Eklund, Susanne CM Reinhardt, Ian A Parish, Ralf Jungmann, Maartje MC Bastings

2023-12-21

Dendritic cells (DCs) regulate immune priming by expressing programmed death ligand 1 (PD-L1) and PD-L2, which interact with the i..

Spatially Controlled Activation of Toll-like Receptor 9 with DNA-Based Nanomaterials

A Comberlato, MM Koga, S Nüssing, IA Parish, MMC Bastings

2022-03-23

First evidence of geometrical patterns and defined distances of biomolecules as fundamental parameters to regulate receptor bindin..

Quantification of Strand Accessibility in Biostable DNA Origami with Single-Staple Resolution

AS Eklund, A Comberlato, IA Parish, R Jungmann, MMC Bastings

2021-11-23

DNA-based nanostructures are actively gaining interest as tools for biomedical and therapeutic applications following the recent d..

Revisiting T Cell Tolerance as a Checkpoint Target for Cancer Immunotherapy

S Nüssing, JA Trapani, IA Parish

2020-09-23

Immunotherapy has revolutionized the treatment of cancer. Nevertheless, the majority of patients do not respond to therapy, meanin..

Efficient CRISPR/Cas9 gene editing in uncultured naive mouse T cells for in vivo studies

S Nü Ssing, IG House, CJ Kearney, AXY Chen, SJ Vervoort, PA Beavis, J Oliaro, RW Johnstone, JA Trapani, IA Parish

2020-04-15

CRISPR/Cas9 technologies have revolutionized our understanding of gene function in complex biological settings, including T cell i..